غنو
31/05/04, 04 :38 04:38:54 AM
Coronary artery disease
The heart muscle must have an adequate blood supply to contract properly if the coronary artery is narrowed or blocked, the area of the heart muscle supplied by that artery becomes ischemic and injured, and infarction may result the major disorders due to insufficient blood supply to the myocardium are angina pectoris, congestive heart failure and myocardial infraction.
Coronary artery disease by itself does not necessarily produce symptoms for manifestations to develop there must be critical deficit in blood supply to the heart
symptoms of CAD don't appear until the lumen of the coronary artery narrows by 75%
Pathophysiology
Coronary artery disease: is characterized by the accumulation of fatty deposits along the innermost layer of the coronary artery. The enlarged lesion can cause a critical narrowing of the coronary artery lumen resulting in a decrease in coronary blood flow and an inadequate supply of oxygen to the heart muscle
Pathophysiology
A- The most widely accepted cause of CAD is the accumulation of lipids mainly cholesterol and fibrous materials (smooth muscles cells ) within the coronary artery lumen
A-increase blood levels of low-density lipoprotein irritate and damage the inner layer of the coronary vessels
B-LDL enters the vessels after damaging the protective barrier accumulates and forms fatty streaks are yellow, flat , and cause no significant coronary artery obstruction .
C – smooth muscle cells (from the middle layer of the coronary artery ) move to the inner layer to engulf the fatty substance produce fibrous tissue and stimulate calcium deposition
B-this cycle continues resulting in the transformation of the fatty streak into a fibrous plaque and a complicated CAD lesion evolves
C- the complicated lesion can cause significant coronary abstraction by hemorrhage and ulceration of the plaque
The heart muscle must have an adequate blood supply to contract properly if the coronary artery is narrowed or blocked, the area of the heart muscle supplied by that artery becomes ischemic and injured, and infarction may result the major disorders due to insufficient blood supply to the myocardium are angina pectoris, congestive heart failure and myocardial infraction.
Coronary artery disease by itself does not necessarily produce symptoms for manifestations to develop there must be critical deficit in blood supply to the heart
symptoms of CAD don't appear until the lumen of the coronary artery narrows by 75%
Pathophysiology
Coronary artery disease: is characterized by the accumulation of fatty deposits along the innermost layer of the coronary artery. The enlarged lesion can cause a critical narrowing of the coronary artery lumen resulting in a decrease in coronary blood flow and an inadequate supply of oxygen to the heart muscle
Pathophysiology
A- The most widely accepted cause of CAD is the accumulation of lipids mainly cholesterol and fibrous materials (smooth muscles cells ) within the coronary artery lumen
A-increase blood levels of low-density lipoprotein irritate and damage the inner layer of the coronary vessels
B-LDL enters the vessels after damaging the protective barrier accumulates and forms fatty streaks are yellow, flat , and cause no significant coronary artery obstruction .
C – smooth muscle cells (from the middle layer of the coronary artery ) move to the inner layer to engulf the fatty substance produce fibrous tissue and stimulate calcium deposition
B-this cycle continues resulting in the transformation of the fatty streak into a fibrous plaque and a complicated CAD lesion evolves
C- the complicated lesion can cause significant coronary abstraction by hemorrhage and ulceration of the plaque